In addition to traditional academic courses, the district offers a number of unique programs. For example, at the high school level, Duanesburg offers the Project Lead the Way program; nine distance learning courses; advanced placement classes; three computer labs; advanced industrial arts classes such as Production Systems, Video Editing and Special Education inclusion programs. Focus is also placed on academic intervention services in English, math and social studies. Students in kindergarten through sixth grade receive enrichment through the Gifted and Talented Education (GATE) program. At the elementary level, students are innovative courses including Computer Aided Instruction, the 1000 Book Club, the Morning News Broadcast, a Drug Prevention Awareness program called "Brainstorm," and the Junior Great Books program.

The staff consists of 75 teachers, 78 non-instructional personnel, a secondary school principal, a middle school house principal, an elementary school principal, a psychologist/Committee on Special Education chairperson, two guidance counselors, a social worker, and a part-time student assistance counselor and school resource officer.

District priorities concentrate on preparing students to meet New York State Regents graduation requirements and providing additional assistance, such as Academic Intervention Services (AIS) to students who are struggling to meet the state's learning standards.